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Because of its methotrexate effectiveness, low-dose methotrexate is now first-line therapy for the treatment of rheumatoid arthritis . [12][15][16] Use of methotrexate together with NSAIDS is safe, if adequate monitoring is methotrexate abdominal pain methotrexate 20 mg injection methotrexate 20 mg injection methotrexate done . Weekly doses are beneficial for 12 to 52 weeks duration therapy, methotrexate mg how fast does methotrexate work methotrexate trade name methotrexate and folic acid although discontinuation rates are as high as 16% due to adverse effects . It is used as a disease-modifying treatment for some autoimmune diseases, including rheumatoid arthritis, juvenile dermatomyositis, psoriasis, psoriatic arthritis, methotrexate lupus, sarcoidosis, Crohn's disease (although a recent review has raised the point that it is fairly underused in Crohn's disease),[11] eczema and many forms of vasculitis . [12][13] Although originally designed as a chemotherapy drug (using high doses), in low doses, methotrexate is a generally safe and well tolerated drug methotrexate in the treatment of certain autoimmune diseases . [14] Although methotrexate for autoimmune diseases is methotrexate taken in lower doses than it is for cancer, side effects such as hair loss, nausea, headaches, and skin pigmentation are still common .

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